In the present study the simultaneous estimation of isosorbide dinitrate and hydralazine hydrochloride in combined tablet dosage form have been developed using 0.1 N NaOH in methanol as a solvent by absorption correction method. The method is developed at 222 nm and 252 nm which is the maximum absorbance of isosorbide dinitrate and hydralazine hydrochloride respectively. Beer’s law obeyed in concentration range of 40 - 120 µg/ml and 10 - 50 µg/ml for isosorbide dinitrate and hydralazine hydrochloride respectively. The accuracy of the method was assessed by recovery studies was found to be 99.98±0.3175 and 99.88±1.020 for isosorbide dinitrate and hydralazine hydrochloride. These methods are simple, accurate and rapid; those require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.
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